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    Tamoxifen is the generic name for the most widely used of the SERMs in the treatment of breast cancer; it is usually sold under the trade name Nolvadex. Since the expiration of it's patent in 2002, tamoxifen is now widely available in generic form. Wikipedia Up to 7-10% of women with breast cancer may not receive the full medical benefit from taking tamoxifen, because of their unique genetic make-up. These women have less functional versions of the CYP2D6 gene, which may reduce the effectiveness of tamoxifen and increase their chance of breast cancer recurrence. A medical genetic summary (last updated 2016; [1]), summarizes the Dutch PGx Working Group therapeutic recommendations based on CYP2D6 phenotypes as follows: On Oct 18, 2006 the Subcommittee for Clinical Pharmacology recommended relabeling tamoxifen to include information about this gene in the package insert. A 2009 review of several studies since then mostly confirms worse clinical outcome in patients with decreased CYP2D6 metabolism and supports the notion that CYP2D6 genotype may well become a clinically relevant predictive marker.[PMID 19118028] An additional retrospective study published after this review extended the earlier findings by specifically studying primarily post-menopausal women with early (I-III) stage, ER /PR breast cancer. Based on a median follow-up time of 6 years, this report found that the presence of 2 functional CYP2D6 alleles was associated with better clinical outcomes and the presence of nonfunctional or reduced-function alleles with worse outcomes.[PMID 19809024] However, an argument has also been made that making conclusions based on such studies is still premature, primarily because there are also over ten studies with "widely heterogeneous results with relative-risk estimates outside the range of reasonable bounds".[PMID 19647203] A 2010 study has extended the CYP2D6 risk by also pointing to risk associated with SNP rs3740065 in the ABCC2 gene; patients taking tamoxifen who had all 4 risk alleles at these two genes were said to have a 45 fold higher risk of breast cancer recurrence compared to patients with one or less risk alleles. Tamoxifen Nolvadex ® - ChemoExperts Teva's generic of Nolvadex® Tablets Tamoxifen Citrate Tablets, USP Tamoxifen Nolvadex - A Hematology Oncology Wiki
     
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    To fertilize an egg the old-fashioned way, sperm need to be able to swim. In fact, when IVF technicians use tiny, robotically controlled glass straws to insert a single sperm inside an egg, they sometimes beat the sperm with the glass until it stops moving. The only thing that matters is the DNA inside the sperm. (CBS News) More than 3.7 million babies each year are born with help from fertility treatments. A new Australian study examines the risk for birth defects associated with the different types of assisted reproductive technology. Researchers compared risk of major birth defects - such as cerebral palsy or heart or gastrointestinal defects - among babies born with help of the most commonly available types of fertility treatments, including IVF (in vitro fertilization), ICSI (intracytoplasmic sperm injection) and ovulation induction, by reviewing a South Australian registry of more than 300,000 birth records and 18,000 birth defects. The researchers identified 6,100 assisted reproductive technology births, and found an 8.3 percent risk for any birth defect in pregnancies that involved any type of fertility treatment, compared with a 5.8 percent chance of a birth defect among pregnancies not using assisted conception. There was a 7.2 percent risk of birth defects among babies born through IVF and a 9.9 percent risk for babies born through ICSI. Massive Fertility Study Shows Clomid Birth Defects Risk Common fertility treatments raise birth defect risk, study finds - CBS. Fertility Methods Raise Risk of Birth Defects - ABC News
     
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