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    The aims of this study were to assess the pharmacokinetics and pharmacokinetic/pharmacodynamic (PK/PD) indices predictive of clinical outcome of ciprofloxacin (CIP) and norfloxacin (NOR) after multiple oral dosing, and to investigate their penetration into prostatic fluid in dogs. Prostatic fluid concentrations were lower than plasma concentrations for both drugs. Drug concentrations were determined in blood and in two prostatic fluid samples. No statistically significant differences were determined between the pharmacokinetic parameters calculated after the first and seventh doses for either CIP or NOR. The PK/PD indices were found to be useful for predicting bacteriological outcome for fluoroquinolones (area under the disposition curve/minimum inhibitory concentration [MIC] and peak plasma concentration/MIC) and indicate that with this dose regimen CIP presents a more favourable disposition than NOR for successful clinical outcome. Cipro Dosage Guide - PDF Ciprofloxacin dogs - ResearchGate Ciprofloxacin For Dogs Uses, Dosage, And Side Effects - Dogtime
     
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    Which Viagra Dosage Should I Take? - How often can I take Viagra? You mustn’t take Viagra more than once a day. If you have sex more than twice a week you may find that a different medication, Cialis.

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