Tamoxifen replacement

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  1. speedre13 XenForo Moderator

    Tamoxifen replacement


    Find out what hormone therapy is, when you might have it, and the possible side effects. They control the growth and activity of normal cells. Before the menopause, the ovaries produce the hormones oestrogen and progesterone. After the menopause, oestrogen is made in body fat. These hormones can stimulate the growth of some breast cancer cells. Hormone treatments lower the levels of oestrogen or progesterone in the body, or block their effects. Hormone therapy is only likely to work if the breast cancer cells have oestrogen receptors (ER). Your doctor checks your cancer cells for these receptors when you are diagnosed. Tamoxifen (Nolvadex®) is a medication in pill form that has been used for more than 25 years to treat breast cancer in women and men. Tamoxifen is one of the most common endocrine therapy drugs. It has been shown to decrease the chance of recurrence in some early-stage breast cancers and to prevent the development of cancer in the opposite breast. Tamoxifen can also slow or stop the growth of cancer cells present in the body. There are an estimated 29 million women at increased risk for breast cancer in this country, and tamoxifen may offer another alternative to watchful waiting or prophylactic (preventative) mastectomy. Tamoxifen is classified as a selective estrogen receptor modulator (SERM) and works as an anti-estrogen: While the hormone estrogen promotes the growth of breast cancer cells, tamoxifen works by blocking estrogen from attaching to estrogen receptors on these cells. By blocking the estrogen receptors, it is believed that the growth of the breast cancer cells will be halted.

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    Sep 12, 2009. According to a study, just published in Cancer Research, long-term use of tamoxifen ups the risk of getting aggressive cancer in the other. Tamoxifen. Tamoxifen Nolvadex has been used for over 40 years to treat hormone-receptor positive early, locally advanced and metastatic breast cancers. Climacteric. 2002 Jun;52151-5. Tamoxifen, hormone receptors and hormone replacement therapy in women previously treated for breast cancer a cohort.

    Hormones are substances that function as chemical messengers in the body. They affect the actions of cells and tissues at various locations in the body, often reaching their targets through the bloodstream. The hormones estrogen and progesterone are produced by the ovaries in premenopausal women and by some other tissues, including fat and skin, in both premenopausal and postmenopausal women and men. Estrogen promotes the development and maintenance of female sex characteristics and the growth of long bones. Progesterone plays a role in the menstrual cycle and pregnancy. Estrogen and progesterone also promote the growth of some breast cancers, which are called hormone-sensitive (or hormone-dependent) breast cancers. Hormone-sensitive breast cancer cells contain proteins called hormone receptors that become activated when hormones bind to them. Women taking a new breast cancer drug are living longer than those taking Tamoxifen - the current 'gold standard' treatment. Doctors predict the new drug, Arimidex, will improve long-term survival for women using hormonal therapy for the first time in decades. Claimed as the biggest breakthrough in treatment for 20 years, it is the first drug to challenge tamoxifen, the standard treatment for postmenopausal women after surgery. Trial results out yesterday show the risk of a relapse within four years of surgery is cut by almost a fifth more in women taking Arimidex. Only 413 of 3,125 women taking the new drug had a breast cancer relapse or died compared with 472 of 3,116 women using tamoxifen. The latest research findings show Arimidex is much more effective than tamoxifen, which is normally used to stop patients successfully treated with surgery from developing a tumour in the other breast. Previous trial results found that although tamoxifen halves the risk of a new cancer in the other breast - Arimidex halves it again.

    Tamoxifen replacement

    The effect of tamoxifen and hormone replacement therapy on serum., Tamoxifen for Breast Cancer Treatment - Side Effects Susan G.

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  7. May 18, 2016. Tamoxifen sold as Nolvadex and Soltamox, among others, is the most. doctors continue to prescribe synthetic hormone replacement drugs.

    • Tamoxifen Alternatives for Estrogen Dominant Breast Cancer.
    • Tamoxifen, hormone receptors and hormone replacement therapy in..
    • Should aromatase inhibitors replace tamoxifen? - NCBI.

    Because tamoxifen acts like estrogen in tissue other than breast tissue, women who take tamoxifen may derive some of the benefits of estrogen replacement. Oct 3, 2010. The results are the latest analysis from the large ATAC Arimidex and Tamoxifen Alone or in Combination study. The ATAC study compared. Women taking a new breast cancer drug are living longer than those taking Tamoxifen - the current 'gold standard' treatment.

     
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