Prednisolone chemical structure

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    Prednisolone chemical structure


    A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states. Prednisone is a drug that belongs to the class of corticosteroids which is a steroid. Steroids are hormones with similar chemical structure that gather together as a group. In general, Prednisone is produced by your adrenal gland which is located on top of kidneys. It is used to treat people who have low levels of corticosteroids. It works in preventing the flammable substances in the body. Patients with the following conditions can be treated with Prednisone: skin conditions, lupus, arthritis, breathing disorder, or allergic disorder at regular doses, or it can be treated with cancer at higher doses. This drug is no t highly recommended since it has really severe side effects.

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    State Solid; Experimental Properties. data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. Prednisolone INN is a synthetic steroid that is chemically defined as 11b,17a,21-trihydroxy- pregna-1,4-diene-3,20-dione. Its structure is shown in Figure 1. The chemical name of prednisolone sodium prednisolone sodium phosphate oral. sodium phosphate oral solution Phosphate Structural Formula Illustration.

    Corticosteroids inhibit the inflammatory response to a variety of inciting agents and probably delay or slow healing. They inhibit the edema, fibrin deposition, capillary dilation, leukocyte migration, capillary proliferation, fibroblast proliferation, deposition of collagen, and scar formation associated with inflammation. There is no generally accepted explanation for the mechanism of action of ocular corticosteroids. However, corticosteroids are thought to act by the induction of phospholipase A inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A Steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe such as allergic conjunctivitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, selected infective conjunctivitides, when the inherent hazard of steroid use is accepted to obtain an advisable diminution in edema and inflammation; corneal injury from chemical, radiation, or thermal burns, or penetration of foreign bodies. Prednisolone Acetate Ophthalmic Suspension USP, 1% is contraindicated in most viral diseases of the cornea and conjunctiva including epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and varicella, and also in mycobacterial infection of the eye and fungal diseases of ocular structures. Prednisolone acetate ophthalmic suspension (eye drops) is an adrenocortical steroid product, prepared as a sterile ophthalmic suspension and used to reduce swelling, redness, itching, and allergic reactions affecting the eye. Although there are no major human studies of prednisolone use in pregnant women, studies in several animals show that it may cause birth defects including increase cleft palate. Prednisolone should be used in pregnant women when benefits outweigh the risks and children born from mothers using prednisolone during pregnancy should be monitored for impaired adrenal function. Prednisolone is found in breast milk of mothers taking prednisolone. As a glucocorticoid, the lipophilic structure of prednisolone allows for easy passage through the cell membrane where it then binds to its respective glucocorticoid receptor (GCR) located in the cytoplasm. Upon binding, formation of the GC/GCR complex causes dissociation of chaperone proteins from the glucocorticoid receptor enabling the GC/GCR complex to translocate inside the nucleus. Once inside the nucleus, the homodimer GC/GCR complex binds to specific DNA binding-sites known as glucocorticoid response elements (GREs) resulting in gene expression or inhibition. Complex binding to positive GREs leads to synthesis of anti-inflammatory proteins while binding to negative GREs block the transcription of inflammatory genes.

    Prednisolone chemical structure

    Prednisolone ≥99% Sigma-Aldrich, Prednisolonelink href='#fn1' - Wiley Online Library

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  5. DRUG Prednisolone, Help. Formula. C21H28O5. Exact mass. 360.1937. Mol weight. 360.444. Structure, Mol file KCF. Chemical structure group DG00093.

    • KEGG DRUG Prednisolone.
    • Prednisolone Oral Solution Prednisolone Sodium Phosphate Oral..
    • Prednisone C21H26O5 - PubChem.

    Chemical Structure. Related Chemicals, Prednisone in vivo is converted in the liver to prednisolone. Drug Interactions, Prednisolone sodium phosphate. Prednisolone is a steroid medication used to treat certain types of allergies, inflammatory. 3 Pharmacology; 4 Chemistry; 5 Society and culture. As a glucocorticoid, the lipophilic structure of prednisolone allows for easy passage through the. Prednisolone tebutate C27H38O6 CID 93055 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological.

     
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