According to almost every beauty article I read these days it is just about the only thing that works on wrinkles. There are derivative in cosmetics such as retinal etc but they are not strong enough to be effective I think. What's the reasoning behind bit prescribing it anymore? Trying for a baby at the mo so staying away for the time being but intend to get involved big time once my baby making days are done. You can get A313 on ebay which is similar to Avibon which was v sadly discontinued, you used to be able to buy it over the counter in France. It's a slightly lower concentration than prescription retin a so might be a good place to start United Pharmacies are the online pharmacy. Obagi Nu-Derm uses 0.1% tretinoin (pea sized amount) mixed in the hand at time of application with similar amount of hydroquinone cream. It was found that this combination actually switches on the DNA which produces collagen. (This is what they told me on the Obagi course anyway...). 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