Tamoxifen uses in males

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    Tamoxifen uses in males


    Tamoxifen for Low Testosterone in Males My previous article discussed the use of clomiphene for increasing testosterone in hypo-gonadal males. Clomiphene works as an estrogen receptor blocker in the hypothalamus, thus stimulating LH/FSH which then stimulate testicular testosterone production. Tamoxifen Another drug which similarly blocks estrogen receptors is Tamoxifen (tamoxiphen), commonly used in breast cancer survivors to block estrogen receptors. Similar to the use of clomiphene, tamoxiphen has been used to treat low testosterone and low sperm counts (infertility) in males. (1-3) Usual dosage is 10-20 mg tamoxifen per day for 6 to 9 months.(1-3) Reduction of Growth Hormone Levels by Tamoxifen An unwanted effect of tamoxifen is 25% reduction in IGF-1 (growth hormone) levels.(5) Tamoxifen reduced peak Growth Hormone levels in mice by 60%.(6) Ocular Toxicity Adverse effects of tamoxifen relate to the ocular toxicity. Regular eye exams at the ophthalmology office every 6 months is advised (4) Articles with related interest: pubmed/640052 Fertil Steril. Hormonal effects of an antiestrogen, tamoxifen, in normal and oligospermic men. The administration of tamoxifen, 20 mg/day for 10 days, to normal males produced a moderate increase in luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, and estradiol levels, comparable to the effect of 150 mg of clomiphene citrate (Clomid). However, whereas Clomid produced a decrease in the LH response to LH-releasing hormone (LHRH), no such effect was seen after the administration of tamoxifen. About half of male breast cancer patients who take the drug tamoxifen to prevent their disease from returning report side effects such as weight gain and sexual dysfunction, which prompts more than 20 percent of them to discontinue treatment, according to researchers at The University of Texas MD Anderson Cancer Center. The study, which is the largest to date of how the estrogen-blocking drug is tolerated in men with breast cancer, was published today in the journal Annals of Oncology."While tamoxifen is effective in treating breast cancer in men, little is known about its toxicity," said Sharon Giordano, M. D., associate professor of medicine in MD Anderson's Department of Breast Medical Oncology and senior author of the study. "This research will help doctors and patients better understand the side effects men experience. With this information, patients can make more informed decisions about treatment risks and benefits."Few Empirical Studies of Rare Disease Only about 2,000 men are diagnosed with breast cancer in the United States each year, but its incidence is increasing. Since the disease is so rare, little published evidence exists to guide treatment decisions, and most are based on what works in women. There is limited data about the toxicity of anti-hormonal treatments in men.

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    Nov 16, 2011. About half of male breast cancer patients who take the drug tamoxifen to prevent their disease from returning report side effects such as weight. Uses. Tamoxifen is used to treat breast cancer. It is also used to reduce the chances of breast cancer in high-risk patients. This medication can block the growth of breast cancer. May 6, 2016. Tamoxifen is an off-label option to treat men for breast cancer, infertility. Hormonal/therapeutic use; Breast Neoplasms, Male/drug therapy*.

    The hormonal therapy tamoxifen (brand name: Nolvadex) is commonly used to treat men who've been diagnosed with breast cancer. Breast cancer is a rare disease in men, but it does happen. A study has found that many men have problems while taking tamoxifen and about 20% of them stop taking it (either on their own or as directed by their doctors) because of unacceptable side effects. About 2,100 new cases of invasive breast cancer are expected to be diagnosed in men in 2011. A man's lifetime risk of breast cancer is about 1 in 1,000. As in women, most male breast cancer is hormone-receptor-positive. The hormones estrogen and progesterone can potentially support the growth and spread of hormone-receptor-positive breast cancers. So hormonal therapy that blocks the effect of these hormones -- like tamoxifen -- can be a good treatment option for hormone-receptor-positive breast cancer in both men and women. In this study, the researchers looked at the treatment records of 126 men diagnosed with breast cancer between 19. Hormone therapy (sometimes called endocrine therapy) is a way to treat cancer by using hormones or drugs or other treatments that affect hormones. Hormone therapy is a form of systemic therapy, like chemotherapy. It can be used after surgery (adjuvant therapy) to help lower the risk of cancer coming back, or before surgery (neoadjuvant treatment). It is also used to treat cancer that has spread, or cancer that has come back after treatment (recurred). Some breast cancers grow in response to the hormones estrogen or progesterone. Estrogen and progesterone are usually thought of as female hormones, but men have them in their bodies also, just at lower levels. About 9 of 10 breast cancers in men are hormone receptor-positive.

    Tamoxifen uses in males

    Use of high dose tamoxifen in males documented to have., Tamoxifen Oral Uses, Side Effects, Interactions, Pictures.

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  3. Find patient medical information for Tamoxifen Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.

    • Tamoxifen Oral Uses, Side Effects, Interactions, Pictures, Warnings..
    • Tamoxifen in men a review of adverse events. - NCBI.
    • Tamoxifen Side Effects in Detail -.

    Nov 17, 2011. As in women, most male breast cancer is hormone-receptor-positive. The hormones estrogen and progesterone can potentially support the. May 6, 2016. Study designs, which were not RCTs, such as case reports, observational and retrospective studies describing tamoxifen use in men, were. For men, tamoxifen can cause * headache * nausea and vomiting * skin rash * sexual side effects like erectile dysfunction or a lower sex drive.

     
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